Cue effects on methylphenidate self-administration in rats
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چکیده
منابع مشابه
Inhibitory effects of ibogaine on cocaine self-administration in rats.
In order to determine the potential anti-addictive properties of ibogaine, we used the cocaine self-administration model in rats. The results indicate that a single injection of ibogaine (40 mg/kg i.p.) produced a significant decrease of cocaine intake, which remained unaltered for more than 48 h. Since the half-life time of ibogaine is short, this might suggest the involvement of one or severa...
متن کاملEffects of repeated administration of methylphenidate on reproductive parameters in male rats
Methylphenidate (MPH) is a psychostimulant drug which acts by blocking the dopamine and norepinephrine transporters and is the main drug used to treat attention deficit hyperactivity disorder in children and adolescents. During puberty, changes in neurotransmitter systems (including dopaminergic system) are engaged on the release of gonadal hormones and the development of cephalic structures re...
متن کاملEffects of chronic oral methylphenidate on cocaine self-administration and striatal dopamine D2 receptors in rodents.
BACKGROUND Methylphenidate (MP) and amphetamine, which are the mainstay for the treatment of ADHD, have raised concerns because of their reinforcing effects and the fear that their chronic use during childhood or adolescence could induce changes in the brain that could facilitate drug abuse in adulthood. METHODS Here we measured the effects of chronic treatment (8 months) with oral MP (1 or 2...
متن کاملMethylphenidate administration determines enduring changes in neuroglial network in rats.
Repeated exposure to psychostimulant drugs induces complex molecular and structural modifications in discrete brain regions of the meso-cortico-limbic system. This structural remodeling is thought to underlie neurobehavioral adaptive responses. Administration to adolescent rats of methylphenidate (MPH), commonly used in attention deficit and hyperactivity disorder (ADHD), triggers alterations o...
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ژورنال
عنوان ژورنال: Behavioural Pharmacology
سال: 2011
ISSN: 0955-8810
DOI: 10.1097/fbp.0b013e32834afed1